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These conclusions situation EBNA-3a just like a essential modulator of B cellular proliferation and survival for the duration of EBV latency, and being a relevant CD8⁺ T cell target in the two simple immunological experiments and translational look into.
Therapeutic vaccine candidates utilizing viral vectors encoding LMP2 have properly induced virus-precise CD8⁺ T cell responses in early-stage clinical trials. On top of that, adoptive T cell therapies like posoleucel also concentrate on LMP2 together with other latency proteins which include EBNA1, reinforcing its importance for a conserved and immunodominant antigen.
Advantages consist of resistance to dewetting, compatibility with a hundred% aqueous cellular phases, choice selectivity to HALO C18 and for a longer time retention of polar compounds than basic C18 phases beneath most cellular stage conditions.
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